| Virus Selector: | ||
| User Name: |
| Virus | Gene Name (Click for gene record) |
Description |
|---|---|---|
| Family: FlaviviridaeGenus: FlavivirusSpecies: Dengue virus type 1 | ||
| DENV-WPNAURUSEQ2 | mp_AnchCap | structural protein participates in encapsidation of viral RNA |
| DENV-WPNAURUSEQ2 | polyprotein | Polyprotein precursor coded by single long ORF and processed in cell on fragments known as viral proteins |
| DENV-WPNAURUSEQ2 | mp_capsid | Viral capsid protein; encapsidation of viral RNA |
| DENV-WPNAURUSEQ2 | mp_preM | Membrane glycoprotein precursor forms envelope of immature dengue virus and masks E-protein fusion with host cell membrane. |
| DENV-WPNAURUSEQ2 | mp_M | viral envelope glycoprotein; induction of apoptosis |
| DENV-WPNAURUSEQ2 | mp_E | Major envelope protein; participates in virus-host receptor binding, in fusion; induces apoptosis. |
| DENV-WPNAURUSEQ2 | mp_NS1 | NS1 exists as three discrete forms, that may have a different functions. The forms are a membrane-associated form, a cell surface-associated form, and a secreted form. NS1 induces an apoptosis in host; participates in virus replication. The sNS1 is immunogen secreted in blood. |
| DENV-WPNAURUSEQ2 | mp_NS2A | NS2A protein |
| DENV-WPNAURUSEQ2 | mp_NS2B | Co-factor of viral serin protease complex NS2B-NS3. |
| DENV-WPNAURUSEQ2 | mp_NS3 | protease activity; helicase; triphosphatase; induction of apoptosis |
| DENV-WPNAURUSEQ2 | mp_NS4A | Nonstructural protein 4A induces membrane alteration. NS4A is important for viral RNA replication (by similarity with DENV-2). |
| DENV-WPNAURUSEQ2 | mp_2K | 2 kDa fragment of Dengue polyprotein (signal peptide of NS4B protein) |
| DENV-WPNAURUSEQ2 | mp_NS4B | Interferon inhibitor; participant in viral RNA replication via NS3 interaction |
| DENV-WPNAURUSEQ2 | mp_NS5 | RNA-directed RNA polymerase; replication complex |
| Family: FlaviviridaeGenus: FlavivirusSpecies: Dengue virus type 2 | ||
| DENV-16681SEQ2 | mp_anchC | Anchored capsid protein |
| DENV-16681SEQ2 | mp_virC | Viral RNA genome packaging |
| DENV-16681SEQ2 | polyprotein | Polyprotein precursor coded by single long ORF and processed in cell on fragments known as viral proteins |
| DENV-16681SEQ2 | mp_prM | Envelope protein of immature virion with role in viral assembly and in protection of protein E from fusion. |
| DENV-16681SEQ2 | mp_M | Virus-host interaction; cell cycle arrest; induction of apoptosis |
| DENV-16681SEQ2 | mp_E | Major envelope protein; participant in replication, in virus-host receptor binding, in fusion, in virus propagation. |
| DENV-16681SEQ2 | mp_NS1 | Virus-host interaction, viral replication; induction of apoptosis; immunogenic secreted protein. |
| DENV-16681SEQ2 | mp_NS2A | Inhibitor of IFN |
| DENV-16681SEQ2 | mp_NS2B | Co-factor of viral serine protease complex NS2B-NS3 |
| DENV-16681SEQ2 | mp_NS3 | Protease; helicase; triphosphatase |
| DENV-16681SEQ2 | mp_NS4A | Inhibitor of IFN; component of viral replication complex |
| DENV-16681SEQ2 | mp_2K | 2 kDa fragment of Dengue polyprotein (signal peptide) |
| DENV-16681SEQ2 | mp_NS4B | Participant in RNA replication; inhibitor of IFN |
| DENV-16681SEQ2 | mp_NS5 | RNA-directed RNA polymerase; 5'-methyltransferase activity |
| Family: FlaviviridaeGenus: FlavivirusSpecies: Dengue virus type 3 | ||
| DENV-D3HIS20001266 | polyprotein | Polyprotein precursor coded by single long ORF and processed in cell on fragments known as viral proteins |
| DENV-D3HIS20001266 | Capsid protein | Mature capsid protein with role in viral RNA genome packaging |
| DENV-D3HIS20001266 | Anchored capsid protein | Anchored capsid protein |
| DENV-D3HIS20001266 | Membrane glicoprotein precursor | Envelope protein of immature virion with role in viral assembly and in protection of protein E from fusion with host cell membrane |
| DENV-D3HIS20001266 | Membrane glycoprotein | Membrane glycoprotein forms envelope of mature dengue virus; participates in virus-host interaction and in apoptosis of cell |
| DENV-D3HIS20001266 | Envelope protein | Major envelope protein involved in virus-host receptor binding, in fusion with host cell membrane. |
| DENV-D3HIS20001266 | Nonstructural protein NS1 | Secreted protein with immunogenic function |
| DENV-D3HIS20001266 | Nonstructural protein NS2A | NS2A protein; viral immunogenic factor |
| DENV-D3HIS20001266 | Nonstructural protein NS2B | Co-factor of viral serine protease complex NS2B-NS3 |
| DENV-D3HIS20001266 | Nonstructural protein NS3 | Serine protease activity in complex with viral NS2B protein; NTP/helicase activity; component of viral replication complex |
| DENV-D3HIS20001266 | Nonstructural protein NS4A | Participant of viral RNA replication, potential inhibitor of IFN (by similarity with DENV-2) |
| DENV-D3HIS20001266 | 2K peptide | 2 kDa fragment of Dengue polyprotein (signal peptide) |
| DENV-D3HIS20001266 | Nonstructural protein NS4B | Participant in viral RNA replication; potential IFN inhibitor (by similarity with other types of dengue virus) |
| DENV-D3HIS20001266 | Nonstructural protein NS5 | RNA-directed RNA polymerase; 5`-methyltransferase activity ; main component of viral replication complex |
| Family: FlaviviridaeGenus: FlavivirusSpecies: Dengue virus type 4 | ||
| DENV-814669SEQ4 | mp_anchored capsid _anchC_ protein | Anchored capsid protein |
| DENV-814669SEQ4 | mp_virion capsid _virC_ protein | Viral RNA genome packaging |
| DENV-814669SEQ4 | polyprotein precursor | Polyprotein precursor coded by single long ORF and processed in cell on fragments known as viral proteins |
| DENV-814669SEQ4 | mp_membrane precursor _prM_ protein | Membrane glycoprotein precursor forms envelope of immature dengue virus and masks E-protein fusion with host cell membrane |
| DENV-814669SEQ4 | mp_membrane _M_ protein | viral envelope glycoprotein of mature virus; induction of apoptosis |
| DENV-814669SEQ4 | mp_envelope _E_ protein | Major envelope viral protein involved in host-virus receptor binding, in fusion with infected host cell and in virus propagation. |
| DENV-814669SEQ4 | mp_NS1 protein | Glycosylated secreted protein circulating in blood after infection; immunogen. Three forms of NS1 with different functions are described for DENV-1 NS1 protein (see VBRC data) |
| DENV-814669SEQ4 | mp_NS2A protein | Viral immunogenic factor |
| DENV-814669SEQ4 | mp_NS2B protein | Viral protease cofactor NS2B (40 aa of NS2B and 184 N- terminus aa of NS3 form a two- component serine protease complex) |
| DENV-814669SEQ4 | mp_NS3 protein | Protease; helicase; triphosphatase |
| DENV-814669SEQ4 | mp_NS4A protein | Participant in viral RNA replication, potential inhibitor of IFN (by similarity with DENV-2) |
| DENV-814669SEQ4 | mp_2K protein | 2 kDa fragment of Dengue polyprotein, signal peptide (by similarity with DENV-2 2K protein) |
| DENV-814669SEQ4 | mp_NS4B protein | Participant in viral RNA replication; potential IFN inhibitor |
| DENV-814669SEQ4 | mp_NS5 protein | RNA-directed RNA polymerase; 5`-methyltransferase activity; main component of viral replication complex |
The above list represents our effort to compile structural and functional information on virus proteins as a part of our effort to curate virus genomes. This manually-curated information is a part of the VBRC Knowledge Database (KDB) and supports our goal to provide literature-based annotations of entire viral genomes. Currently, KDB data for curated genes can be found by clicking on the link for a particular gene above, or by browsing to a gene record located as a result of a user-defined search from the gene search page. We welcome your input and corrections to the provided information.
