Welcome to the Dengue Virus Database (DengueDb)
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You have reached the Dengue Virus Database (DengueDb), which is a
cooperative project of several groups with the
mission of providing to the scientific community studying dengue virus a
comprehensive battery of informational and analytical tools. The Viral
Bioinformatics Resource Center (VBRC), the Immune Epitope Database and
Analysis Resource (IEDB), and the Broad Institute Microbial Sequencing Center
(MSC) are combining forces to acquire and annotate data on dengue virus, and
to develop and utilize new tools to facilitate the study of this group of
organisms.
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From Kuhn RJ, Zhang W, Rossmann MG, et al.
Cell 2002, 108:717-725. |
Structure of Dengue Virus
Modified from Field's Virology, 5th ed. vol.1, ch.33, p.1107
Dengue virus genome structure, polyprotein processing, and cleavage products.
The top row is a representation of the initial polyprotein translation product.
The middle and bottom rows show the peptide precursors and mature protein products
generated by the proteolytic processing cascade. Structural proteins are dark red
and nonstructural proteins are white. The arrows indicate protease cleavage sites
and are colored according to the particular protease responsible for cleavage
(as indicated in the legend).
Why Research Dengue?
Dengue fever and dengue hemorrhagic fever are acute febrile diseases transmitted
to humans by mosquitoes. Dengue is found in the tropics, but it is moving into more
temperate climates, and is considered endemic in parts of North and South America,
Africa, Asia, and Australia. The National Institutes of Health consider dengue
among the most important re-emerging infectious diseases. An estimated 2.5 billion
people live in areas at risk for epidemic transmission. Globally, there are
an estimated 50 to 100 million cases of dengue fever (DF) and several hundred
thousand cases of dengue hemorrhagic fever (DHF) per year. The average case-fatality
rate of DHF ranges from 1% to 5%. Research
goals include studying the mechanisms of infection; developing and testing vaccines
and treatments; learning more about how dengue viruses may elicit antibodies that
enhance infection and exacerbate disease; developing an understanding of genetic
factors that influence the severity of the disease; and identifying biological
markers that might predict whether an individual is protected.
Current Statistics
This release of the dengue database comprises virus information on:
4 Serotypes,
979 Strains, and
13585 Genes
Resource Express
Curated Genes:
Mini-reviews of the functional properties of each viral gene
VBRC Feedback:
Questions, bug reports, and requests for additional features
QUICK LINKS
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VBRC:
The Viral Bioinformatics Resource Center
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Broad MSC:
Broad Institute Microbial Sequencing Center web page for Dengue genomic sequencing
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IEDB:
The Immune Epitope Database and Analysis Resource
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BRC-Central:
Main site for all NIAID Bioinformatics Resource Centers
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Dengue fact sheet:
CDC information on dengue infections
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Dengue Nucleotide Sequences at NCBI:
All Dengue nucleotide sequences available at NCBI
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Dengue Genomes at NCBI:
All complete Dengue genome sequences available at NCBI
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DengueNet:
World Health Organization data for the global epidemiological and virological surveillance of dengue virus outbreaks
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DengueDT-DB:
Dengue virus Drug Target Database
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FlaviTrack:
An annotated database of flavivirus sequences
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